Differential adaptive responses of Staphylococcus aureus to in vitro selection with different antimicrobial peptides.
نویسندگان
چکیده
We subjected Staphylococcus aureus ATCC 29213 to serial passage in the presence of subinhibitory concentrations of magainin 2 and gramicidin D for several hundred generations. We obtained S. aureus strains with induced resistance to magainin 2 (strain 55MG) and gramicidin D (strain 55GR) that showed different phenotypic changes in membrane properties. Both exhibited a change in membrane phospholipid content and an increase in membrane rigidity, while an alteration in net charge compared to that of the control occurred only in the case of 55MG.
منابع مشابه
Differential adaptive responses of Staphylococcus aureus to in vitro selection with 1 different antimicrobial peptides
1 different antimicrobial peptides. 2 3 4 Tahsina Shireen, Madhuri Singh, Tiyasa Das*, Kasturi Mukhopadhyay 5 School of Environmental Sciences, Jawaharlal Nehru University, New Delhi 110067, 6 India. 7 8 9 10 11 12 Running title: antimicrobial peptides and resistance 13 14 15 16 #Corresponding Author 17 Kasturi Mukhopadhyay, Ph.D. 18 School of Environmental Sciences, 19 Jawaharlal Nehru Univers...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 57 10 شماره
صفحات -
تاریخ انتشار 2013